Abstract: Collection of 5-year Cyclocarya paliurus leaves were conducted from April to September of 2017 at cultivation base of artificial C. paliurus forest in Quzhou of Zhejiang province.Determination and analysis was made on total flavonoids, polysaccharides, triterpenoids and flavonoid compounds in leaves.The results showed that the highest content of total flavonoids was 4.28% in May, and the lowest was 3.16% in June. There was extremely significant differences of flavonoid content in May with that in June and July, significant differences with that in April and August.The content of polysaccharides in leaves was the highest in April, and there was significant difference with in the other months.Total saponins content had trend of increase in leaves from April to September, 16.47%, the highest in September.The content of isoquercetin was much higher than that of quercetin and kaempferol in leaves, the mean of 6 months samples occupied 14.23% of total flavonoids and showed a similar dynamic change of total flavonoids.According to the dynamic changes of main active constituents, the best period for leaf collection was in April and May for much content of flavonoids and polysaccharides, while in September for saponins.