Abstract: AP2/ERF （APETALA2/ethylene responsive factor） transcription factors （TFs） affect different hormone signaling pathways to regulate different developmental processes and stress responses, and participate in the regulation of multiple waterlogging response pathways. This article reviews the structure, regulatory mechanism, and involvement of AP2/ERF transcription factors in the process of waterlogging stress. Molecular interaction mechanisms and prospects for future research on AP2/ERF transcription factors under waterlogging stress. In order to further explore this factor. The mechanisms of plant stress regulation and molecular breeding provide important foundations.