Abstract: Experiments were conducted on effect of different antiseptics on different treated bamboo scrimbers (impregnating bamboo bundle, impregnating bamboo scrimber and brushing scrimber). The results showed that Huake-108 and ZJFC-I had good anti-mold effect. While the fluorine, phenolic mixture and boron phenolic mixture had medium effect. Three other water antiseptics had significant difference of performance after treatment of impregnating bundle and scrimber with same concentration. Treatment of scrimber had better effect than that of bundle. Observations were conducted by SEM and FTIR on anatomic structure and chemical composition of scrimber before and after treatment. The results demonstrated that cellulose, hemicellulose and lignin of scrimber without treatment degraded, especially cellulose and hemicellulose, showing that scrimber was easy to mildew. While that treated by ZJFC-I and Huake-108 had weaker degradation, indicating that antiseptics had effect on degradation.